Neuroscience / Neurodegeneration
At Acres Biosciences, we provide specialized in vitro, in vivo, and ex vivo neuroscience services to accelerate the discovery and development of therapies for neurodegenerative and neuroinflammatory diseases. Our team integrates advanced cellular models with translational in vivo systems to deliver data that supports decision-making in early discovery and preclinical development.
Our Services
We specialize in cellular assays, organoid systems, and pharmacology studies that recapitulate key aspects of CNS biology. Our flexible platform supports customizable study designs across Alzheimer’s, Parkinson’s, ALS, multiple sclerosis, and other neurological disorders.
In Vitro Neuroscience Assays
Primary & iPSC-Derived Neuronal Cultures
- Human iPSC-derived neurons, astrocytes, and microglia
- Microglia-containing organoids for Alzheimer’s disease models
- Neuron–glia co-cultures for neuroinflammatory research
Functional Assays
- Calcium flux assays for synaptic activity and excitotoxicity
- Ion channel assays in 96- or 384-well formats
- Cytokine secretion (MSD/ELISA)
- Immunocytochemistry and high-content imaging for neurite outgrowth, synapse density, and protein aggregation
Custom Co-culture & Organoid Models
- Neuron–microglia and neuron–astrocyte interactions
- 3D organoid systems for Alzheimer’s, Parkinson’s, and ALS
- Translational models of neurodegeneration and neuroinflammation
In Vivo Pharmacology
- CNS Delivery: Systemic dosing and direct administration such as intracerebroventricular (ICV) injection
- Pharmacokinetics (PK): CNS exposure, plasma/brain distribution, bioavailability
- Toxicology: Dose-range finding, tolerability, CNS-specific safety monitoring
- Pharmacodynamics (PD): Target engagement biomarkers, cytokine/chemokine readouts, ex vivo brain tissue analysis
- Behavioral Testing: Learning and memory, motor coordination, activity, social interaction
Explore Other Therapeutic Areas
Inflammation & Autoimmune
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