Your San Diego Research Partner

In vivo Services

At Acres Biosciences, we provide comprehensive in vivo services to assess molecules’ efficacy, safety, and early toxicity. With our extensive experience, we are your US partner to advance your in vivo research and ensure the success of your projects.

Explore our comprehensive in vivo pharmacology services.

Our in vivo Services

By Model Types

  • Oncology Model: Syngeneic Model, Xenograft Model, Bioluminescence Model
  • Metabolic Disease Model
  • Inflammation & Autoimmune Model
  • Respiratory Disease Model
  • Fibrosis Model

By Pharmacological Assessments

  • Preclinical Efficacy
  • Pharmacodynamics (PD)
  • Pharmacokinetics (PK)
  • Non-GLP Toxicology

San Diego local Vivarium

Acres Biosciences’ in vivo vivarium is equipped with state-of-the-art, environmentally friendly rodent caging system. Our facility operates at a BSL-II level and is supported by experienced husbandry personnel, a dedicated attending veterinarian, and comprehensive IACUC services. 

Expedite Your Preclinical Study

Comprehensive In Vivo Study Design and Execution

We design in vivo studies to fit specific research needs, offering flexible options for dosing, sample collection, and study endpoints. Our approach helps ensure accurate results, supporting successful preclinical research.

01.

Study Design and Customization

  • Animal selection
  • Custom time points/timeline
  • Crossover studies
  • Dose proportionality studies
  • Single or repeated-dose studies
  • Customized fed/fasting conditions
  • Special populations
  • Gender-specific studies
  • In-life observations

02.

Drug Dosing Administration

  • Intravenous (IV) or IV cannulation
  • Oral (PO) administration
  • Intraperitoneal (IP) injection
  • Intramuscular (IM) injection
  • Subcutaneous (SC) injection

03.

Dosing Methods

  • Single or repeated dosing
  • Cassette dosing

04.

Customized Sample Collection

  • Serial or terminal sampling
  • Blood (plasma/serum) sampling (cheek vein, retro-orbital vein, saphenous vein, tail vein, jugular vein et al.)
  • Urine
  • Biological fluid sampling
  • Tissue sampling

05.

Endpoints

  • Body weight monitoring
  • Clinical observations
  • Physical examinations
  • Gross necropsy findings
  • Organ weights
  • Neurological examinations
  • Histopathological evaluations
  • Hematology tests
  • Biochemistry assessments
  • Biomarker analyses

06.

PK Analysis

  • Cmax (Maximum Concentration)
  • Tmax (Time to Maximum Concentration)
  • AUC0-t, AUC∞ (Area Under the Curve)
  • BA (Absolute Bioavailability)
  • Ke (Elimination Rate Constant)
  • t1/2 (Half-life)
  • C0 (Initial Concentration)
  • Vd (Volume of Distribution)
  • CL (Clearance Rate)
AcresBioSciences: Scientist planning cell line engineering and assay development on workboard to empower drug development

Related solutions

Cell-based Assays

Our cell-based assay development service leverages cell biology to craft robust assays, providing invaluable insights into hit/lead efficacy, toxicity, and mechanism of action for your research.

Get In Touch with us

AcresBiosciences: Scientist responding to customer inquiries about cell line engineering and assay services