In vivo Services
At Acres Biosciences, we provide comprehensive in vivo services to assess molecules’ efficacy, safety, and early toxicity. With our extensive experience, we are your US partner to advance your in vivo research and ensure the success of your projects.
Explore our comprehensive in vivo pharmacology services.
Our in vivo Services
By Model Types
- Oncology Model: Syngeneic Model, Xenograft Model, Bioluminescence Model
- Metabolic Disease Model
- Inflammation & Autoimmune Model
- Respiratory Disease Model
- Fibrosis Model
By Pharmacological Assessments
- Preclinical Efficacy
- Pharmacodynamics (PD)
- Pharmacokinetics (PK)
- Non-GLP Toxicology
San Diego local Vivarium
Acres Biosciences’ in vivo vivarium is equipped with state-of-the-art, environmentally friendly rodent caging system. Our facility operates at a BSL-II level and is supported by experienced husbandry personnel, a dedicated attending veterinarian, and comprehensive IACUC services.
Expedite Your Preclinical Study
Comprehensive In Vivo Study Design and Execution
We design in vivo studies to fit specific research needs, offering flexible options for dosing, sample collection, and study endpoints. Our approach helps ensure accurate results, supporting successful preclinical research.
01.
Study Design and Customization
- Animal selection
- Custom time points/timeline
- Crossover studies
- Dose proportionality studies
- Single or repeated-dose studies
- Customized fed/fasting conditions
- Special populations
- Gender-specific studies
- In-life observations
02.
Drug Dosing Administration
- Intravenous (IV) or IV cannulation
- Oral (PO) administration
- Intraperitoneal (IP) injection
- Intramuscular (IM) injection
- Subcutaneous (SC) injection
03.
Dosing Methods
- Single or repeated dosing
- Cassette dosing
04.
Customized Sample Collection
- Serial or terminal sampling
- Blood (plasma/serum) sampling (cheek vein, retro-orbital vein, saphenous vein, tail vein, jugular vein et al.)
- Urine
- Biological fluid sampling
- Tissue sampling
05.
Endpoints
- Body weight monitoring
- Clinical observations
- Physical examinations
- Gross necropsy findings
- Organ weights
- Neurological examinations
- Histopathological evaluations
- Hematology tests
- Biochemistry assessments
- Biomarker analyses
06.
PK Analysis
- Cmax (Maximum Concentration)
- Tmax (Time to Maximum Concentration)
- AUC0-t, AUC∞ (Area Under the Curve)
- BA (Absolute Bioavailability)
- Ke (Elimination Rate Constant)
- t1/2 (Half-life)
- C0 (Initial Concentration)
- Vd (Volume of Distribution)
- CL (Clearance Rate)

Related solutions
Cell-based Assays
Our cell-based assay development service leverages cell biology to craft robust assays, providing invaluable insights into hit/lead efficacy, toxicity, and mechanism of action for your research.
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