Fibrosis
At Acres Biosciences, we offer specialized fibroblast-focused in vitro, in vivo and ex vivo services to accelerate discovery and development of anti-fibrotic and anti-inflammatory therapies. Our team combines deep biological expertise with customizable study designs across key disease indications—including IPF, IBD, liver fibrosis, and rheumatoid arthritis.
Our Services
We provide fibroblast-focused in vitro, in vivo, and ex vivo services to support preclinical research in fibrosis and inflammatory diseases. Our platform combines primary cell-based assays and disease-relevant models to generate actionable data across key tissue systems.
In Vitro Fibrosis Assays
Primary Human Fibroblast Cultures
- Lung, colon, liver, and synovial fibroblasts
- Cell banking available for repeat studies
Functional Assays
- Fibroblast activation & differentiation (TGF-β, IL-1β, TNF-α)
- Scar-in-a-jar model: Collagen & fibronectin quantification via high-content imaging
- ECM profiling: ELISA-based detection of matrix components
- Cytokine secretion: Luminex/MSD or ELISA
- Western blot, qPCR, and immunocytochemistry readouts
Custom Co-culture Models
- Epithelial-fibroblast or immune-fibroblast interactions
- Supports translational research in IBD, RA, and fibrosis
In Vivo Disease Models and Ex vivo Assays
Idiopathic Pulmonary Fibrosis (IPF)
- Bleomycin-induced lung fibrosis
- Histology, ECM quantification, BAL Cytokine profiling
Inflammatory Bowel Disease (IBD)
- DSS and TNBS colitis
- Fibroblast remodeling and cytokine profiling
Liver Fibrosis
- CCl₄-induced acute injury
- Bile duct ligation (BDL) chronic fibrosis model
Rheumatoid Arthritis (RA)
- Collagen-induced arthritis (CIA)
- Joint inflammation, synovial fibroblast expansion, histological scoring
Analytical Readouts
- Histopathology, IHC, qPCR
- Hydroxyproline, cytokine panels, fibrosis biomarkers
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