Immuno-Oncology
At Acres Biosciences, we provide tailored, high-quality immuno-oncology (IO) services to accelerate your drug discovery and development efforts. With deep expertise in human immune cell biology and tumor-immune dynamics, our team enables precise evaluation of immunotherapies across both in vitro and in vivo platforms.
Our Services
We provide immuno-oncology–focused in vitro, in vivo, and ex vivo services to support preclinical research in cancer immunotherapy. Our platform integrates human immune cell–based assays and tumor-relevant models to generate actionable data on immune modulation, anti-tumor efficacy, and biomarker response.
In Vitro Immuno-Oncology Assays
Effector Cell Isolation
- Peripheral Blood Mononuclear Cell (PBMC)
- CD4+ / CD8+ T cells
- Regulatory T cells (Tregs)
- Monocytes
- Natural Killer (NK) cells
T Cell Assays
- T cell killing assay
- T cell activation assay (CD69, CD25, etc.)
- T cell proliferation assay (CFSE dye dilution, Ki-67 staining, etc.)
- Cytokine response (Luminex/MSD or ELISA)
NK Cell Assays
- Antibody-dependent cytotoxicity (ADCC) assays
- NK cell phenotyping assays
- Degranulation (CD107a), Granzyme B, and IFN-γ assays
Cytokine Release Assays
- Whole blood or PBMC-based cytokine release profiling
- Evaluate immune activation risk for TCEs, bispecifics, and other biologics
- Multiplex detection of key cytokines (e.g., IL-6, TNF-α, IFN-γ, IL-1β, etc.)
- Supports early risk assessment for cytokine storm potential
In Vivo Immuno-Oncology Services
In Vivo Immuno-Oncology Models
- Syngeneic tumor models (e.g., CT26, MC38) in immunocompetent mice for evaluating immune checkpoint inhibitors, antibody-drug conjugates (ADCs), and targeted cancer therapies
- Humanized xenograft models, including humanized CD34+ (huCD34) and humanized PBMC (huPBMC) mice, for assessing T cell engagers, CAR-T cell therapies, and other immune-modulating agents in a human immune system context
Analysis Methods & Endpoints
- Immune cell infiltration and tumor microenvironment analysis
- Peripheral and tissue-based biomarker monitoring
- Pathology, histology & immunohistochemistry (IHC)
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